Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cai, X.; Wang, X.; Cao, C.; Gao, Y.; Zhang, S.; Yang, Z.; Liu, Y.; Zhang, X.; Zhang, W.; Ye, L.
    HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor et-7g (2018), Cancer Lett., 415, 11-19 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Homo sapiens Q86U44
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.348 breast cancer cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.348 methyltransferase-like 3
-
 Homo sapiens
2.1.1.348 METTL3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.348 Homo sapiens hepatitis B X-interacting protein (HBXIP) up-regulates METTL3 by suppressing let-7g, in which METTL3 increases HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer. Expression of METTL3 is positively related to that of HBXIP in clinical breast cancer tissues up

General Information

EC Number General Information Comment Organism
2.1.1.348 physiological function the enzyme (METTL3) is involved in RNA metabolism through N6-methyladenosine modification. The oncoprotein HBXIP up-regulates METTL3 by inhibiting the expression of tumor suppressor let-7g in breast cancer. METTL3 increases the expression of HBXIP, forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP in breast cancer cells Homo sapiens